Rao, Jagannadha A and Prasad, KSS and Sharma, SC and Subbarayan, VSR (1995) Role of 17\beta-Estradiol and Progesterone in the Regulation of Synthesis and Secretion of Chorionic Gonadotropin by the First Trimester Human Placenta. In: The Journal of Steroid Biochemistry and Molecular Biology, 53 (1-6). pp. 233-239.
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The role of 17\beta-estradiol and progesterone in the regulation of synthesis of chorionic gonadotropin (CG) by first trimester human placenta has been studied using 1,4,6 androstatriene 3-17-dione to block the synthesis of 17\beta-estradiol or tamoxifen to block its action at receptor level and RU486 to block the action of progesterone at the receptor level. Results indicate that the synthesis of CG is negatively modulated by 17\beta-estradiol and positively modulated by progesterone as judged by the change in the levels of immunoreactive CG, \alpha and \beta-CG mRNA and in vitro translation, as well as biosynthesis of \alpha and \beta-CG and, finally, nuclear run off transcription.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier B.V.|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Division of Biological Sciences > Biochemistry
|Date Deposited:||30 Jun 2008|
|Last Modified:||19 Sep 2010 04:46|
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