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Distribution of adriamycin in tissues and subcellular fractions

Muhammed, H and Kurup, * and Ramakrishna, CK (1983) Distribution of adriamycin in tissues and subcellular fractions. In: Indian Journal of Biochemistry and Biophysics, 20 (6). pp. 349-352.

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Abstract

Substantial amounts of adriamycin [23214-92-8] were recovered in various organs after i.p. administration in rats. The highest concenration of the drug was found in the kidneys. Subcellularly, in heart, liver, and kidney, the nuclear fraction contained the highest concentration of the drug, an observation consistent with the finding that adriamycin shows greater affinity for the nuclear fraction when added to tissue homogenates in vitro. These results are discussed in relation to the cardiotoxicity of adriamycin. Procedures for improving the fluorometric method for the detection of adriamycin are also given.

Item Type: Journal Article
Additional Information: copyright of this article belongs to National Institute of Science Communication and Information Resources.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 07 Jul 2008
Last Modified: 27 Aug 2008 13:30
URI: http://eprints.iisc.ernet.in/id/eprint/14644

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