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Role of CYP1B1, MYOC, OPTN and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients

Kumar, Arun and Basavaraj, Manjunath G and Gupta, Santosh K and Qamar, Imteyaz and Ali, Abdullah Mahmood and Bajaj, Vineeta and Ramesh, TK and Prakash, Ravi D and Shetty, Jyoti S and Dorairaj, Syril K (2007) Role of CYP1B1, MYOC, OPTN and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients. In: Molecular Vision, 13 (73). pp. 667-676.

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Abstract

Mutations in the CYP1B1, MYOC, OPTN, and WDR36 genes result in glaucoma. Given its expression in the optic nerve, it is likely a mutation in the OPTC gene is also involved in initiating glaucoma. This study was designed to evaluate the involvement of the CYP1B1, MYOC, OPTN, and OPTC genes in the etiology of adult-onset primary open-angle glaucoma (POAG) found in 251 Indian patients.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Molecular Vision.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Date Deposited: 27 Jun 2008
Last Modified: 19 Sep 2010 04:46
URI: http://eprints.iisc.ernet.in/id/eprint/14650

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