Balaram, P (1985) Proton NMR studies of peptide conformations. In: Proceedings of Indian Academy of Sciences, Chemical Sciences, 95 (1-2). pp. 21-38.
This article reviews recent $^1H$ NMR studies on peptides carried out in the author's laboratory. Methods for the delineation of hydrogen bonded NH groups are discussed and exemplified by studies of conformationally constrained peptides. The application of concentration dependences of NMR parameters for NH groups in peptides to the study of peptide aggregation in apolar solvents is considered. Investigations on chemotactic peptide analogs and suzukacillin fragments are briefly summarized. Nuclear-Overhauser effect studies on \beta -sheet and , \beta -turn confornational models are described. NMR studies on conformational transitions accompanying dissolution of single crystals are illustrated by a study of a peptide containing a -Pro-Pro- segment.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to American Chemical Society.|
|Keywords:||Nuclear magnetic resonance;peptide conformation;hydrogen bonding;peptide aggregation;nuclear-Overhauser effects.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||24 Jul 2008|
|Last Modified:||19 Sep 2010 04:46|
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