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Effect of intranasal administration of norethisterone and progesterone on pituitary and gonadal function in adult male and female bonnet monkeys (Macaca radiata)

Moudgal, Raghuveer N and Rao, Addicam Jagannadha and Murthy, Ganti SRC and Neelakanta, Ravindranath and Banavar, Srinath R and Kotagi, Shidramappa G and Kumar, Trichnopoli C (1985) Effect of intranasal administration of norethisterone and progesterone on pituitary and gonadal function in adult male and female bonnet monkeys (Macaca radiata). In: Fertility and Sterility, 44 (1). pp. 120-124.

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Abstract

The effect of intranasal spray of norethisterone (NET) [68-22-4] and progesterone (P) [57-83-0] on serum testosterone (T) [58-22-0] and total sperm count in adult male bonnet monkeys and the effect of NET spray on the menstrual cycle in female monkeys was studied. Whereas NET spray resulted in a drastic decrease in serum T levels and sperm count, P spray caused a decrease in total sperm count only. Intranasal spray of NET in adult cycling female monkeys between days 5 and 14 shortened the menstrual cycle ascribed to a decrease in serum FSH [9002-68-0], LH [9002-67-9], 17$\beta$-estradiol [50-28-2], and P levels. Nasal spray of only solvent in male or female monkeys had no effect on any of the parameters tested

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 26 Jun 2008
Last Modified: 27 Aug 2008 13:31
URI: http://eprints.iisc.ernet.in/id/eprint/14701

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