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Poly(dG-dC) in the Z-form inhibits E. coli DNA polymerase I and AMV DNA polymerase activity

Brahmachari, SK and Ramesh, N and Das, MR and Parnaik, VK (1985) Poly(dG-dC) in the Z-form inhibits E. coli DNA polymerase I and AMV DNA polymerase activity. In: Biochemistry International, 11 (13). pp. 281-290.

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Abstract

The effect of Z-conformation of DNA on its template activity in DNA synthesis reactions in vitro has been studied. Normal poly(dG-dC) in the B-form, brominated and unbrominated in the Z-form have been compared for their template activity in DNA synthesis reactions mediated by AMV DNA polymerase and E. coli DNA polymerase I. The results indicate that poly(dG-dC) in the Z-form is totally inactive as a template for DNA synthesis and further that it is a strong competitive inhibitor of copying of the B-form DNA.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to American Chemical Society. Biochemistry International currently does not have a website
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Division of Biological Sciences > Biochemistry
Date Deposited: 04 Jul 2008
Last Modified: 27 Aug 2008 13:32
URI: http://eprints.iisc.ernet.in/id/eprint/14751

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