Vijay, NNV and Vasantika, * and Ajmani, Rahul and Perelson, Alan S and Dixit, Narendra M (2008) Recombination increases human immunodeficiency virus fitness, but not necessarily diversity. In: Journal of General Virology, 89 . pp. 1467-1477.
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Recombination can facilitate the accumulation of mutations and accelerate the emergence of resistance to current antiretroviral therapies for human immunodeficiency virus (HIV) infection. Yet,since recombination can also dissociate favourable combinations of mutations, the benefit of recombination to HIV remains in question. The confounding effects of mutation, multiple infections of cells, random genetic drift and fitness selection that underlie HIV evolution render the influence of recombination difficult to unravel. We developed computer simulations that mimic the genomic diversification of HIV within an infected individual and elucidate the influence of recombination. We find, interestingly, that when the effective population size of HIV is small,recombination increases both the diversity and the mean fitness of the viral population. When the effective population size is large, recombination increases viral fitness but decreases diversity. Ineffect, recombination enhances (lowers) the likelihood of the existence of multi-drug resistant strains of HIV in infected individuals prior to the onset of therapy when the effective population size is small(large). Our simulations are consistent with several recent experimental observations,including the evolution of HIV diversity and divergence in vivo. The intriguing dependencies on the effective population size appear due to the subtle interplay of drift, selection and epistasis, which we discuss in the light of modern population genetics theories. Current estimates of the effective population size of HIV have large discrepancies. Our simulations present an avenue for accurate determination of the effective population size of HIV in vivo and facilitate establishment of the benefit of recombination to HIV.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Society for General Microbiology.|
|Department/Centre:||Division of Mechanical Sciences > Chemical Engineering|
|Date Deposited:||07 Jul 2008|
|Last Modified:||19 Sep 2010 04:46|
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