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NMR studies on the conformation of oligomannosides and their interaction with banana lectin

Clavel, Caroline and Canales, Angeles and Gupta, Garima and Santos, Ignacio J and Cañada, Javier F and Penadés, Soledad and Surolia, Avadesha and Jiménez-Barbero, Jesús (2007) NMR studies on the conformation of oligomannosides and their interaction with banana lectin. In: Glycoconjugate Journal, 24 (8). pp. 449-464.

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Abstract

The conformational and dynamic behaviour of three mannose containing oligosaccharides, a tetrasaccharide with \alpha1\rightarrow 2, and \alpha1\rightarrow 3, and a penta and a heptasaccharide with \alpha1\rightarrow 2, \alpha1\rightarrow 3, and \alpha 1\rightarrow 6 linkages has been evaluated by molecular mechanics and dynamics simulations and NMR spectroscopical methods. It is found that they display a fair amount of conformational freedom, with one major and one minor conformation per glycosidic linkage. The evaluation of their recognition by banana lectin has also been performed by STD NMR methods and a preliminary view of their putative interaction mode has been carried out by means of docking procedures.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Springer.
Keywords: Mannose oligosaccharides;NMR;Molecular dynamics;Banana lectin;Molecular recognition.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 18 Jul 2008
Last Modified: 19 Sep 2010 04:47
URI: http://eprints.iisc.ernet.in/id/eprint/15092

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