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Toxicity of the Sesquiterpene Lactone Parthenin to Cultured Bovine Kidney Cells

Narasimhan, TR and Harindranath, N and Premlata, S and Murthy, Kesava BS and Rao, Subba PV (1985) Toxicity of the Sesquiterpene Lactone Parthenin to Cultured Bovine Kidney Cells. In: Planta Medica, 51 (3). pp. 194-197.

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Abstract

The cytotoxic effect of the sesquiterpene lactone, parthenin was studied IN VITRO using cultured bovine kidney cells. The drug inhibited macromolecular synthesis. Fifty percent inhibitions in RNA, DNA and protein synthesis were observed when the cells were treated with parthenin at a final concentration of 1 \mu g/ml. The cytotoxic effect of parthenin was also evident by its ability to markedly inhibit the activities of key cellular enzymes after treatment of the cells with the toxin for 24 h.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Georg Thieme Verlag Stuttgart.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 21 Jul 2008
Last Modified: 27 Aug 2008 13:37
URI: http://eprints.iisc.ernet.in/id/eprint/15126

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