Singh, Sunanda R and Pillai, Beena and Balakrishnan, Bindu and Naorem, Aruna and Sadhale, Parag P (2007) Relative levels of RNA polII subunits differentially affect starvation response in budding yeast. In: Biochemical and Biophysical Research Communications, 356 (1). pp. 266-272.
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The Rpb4/7 subcomplex of RNA polymerase II in Saccharomyces cerevisiae is known to play an important role in stress response and stress survival. These two proteins perform overlapping functions ensuring an appropriate cellular response through transcriptional regulation of gene expression. Rpb4 and Rpb7 also perform many cellular functions either together or independent of one another. Here, we show that Rpb4 and Rpb7 differently affect during the nutritional starvation response pathways of sporulation and pseudohyphae formation. Rpb4 enhances the cells proficiency to sporulate but suppresses pseudohyphal growth. On the other hand, Rpb7 promotes pseudohyphal growth and suppresses sporulation in a dose-dependent manner. We present a model whereby the stoichiometry of Rpb4 and Rpb7 and their relative levels in the cell play a switch like role in establishing either sporulation or pseudohyphal gene expression.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||Stress response;RNA polII; Rpb4;Rpb7;Pseudohyphal growth; Sporulation.|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||28 Jul 2008|
|Last Modified:||19 Sep 2010 04:48|
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