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Gonadotropin-releasing hormone (GnRH) stimulates both secretion and synthesis of human chorionic gonadotropin (hCG) by first trimester human placental minces in vitro

Mathialagan, N and Rao, Jagannadha A (1986) Gonadotropin-releasing hormone (GnRH) stimulates both secretion and synthesis of human chorionic gonadotropin (hCG) by first trimester human placental minces in vitro. In: Biochemistry International, 13 (5). pp. 757-765.

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Abstract

In an in vitro system using the minces of placental villi from first trimester human pregnancy (6-10 wk), addition of low concentration of synthetic gonadotropin-releasing hormone (GnRH) [33515-09-2] or its analogs (D-Phe6-GnRH [57521-78-5] and Buserelin [57982-77-1]) $(1 \times 10^{-8}-1 \times 10^{-6}M)$ increased the quantity of human chorionic gonadotropin (hCG) [9002-61-3] in the medium, whereas addition of high concentrations of GnRH had an inhibitory effect. Of the analogs tested, Buserelin was highly effective in exerting an inhibitory effect. A significant increase in 35S-methionine incorporation into immunoprecipitable hCG was noticed in the presence of GnRH. Evidently, GnRH stimulates both synthesis and secretion of hCG by first trimester human placenta.

Item Type: Journal Article
Additional Information: Biochemistry International does not have a website.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 29 Jul 2008
Last Modified: 27 Aug 2008 13:39
URI: http://eprints.iisc.ernet.in/id/eprint/15339

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