Gratraud, Paul and Surolia, Namita and Besra, Gurdyal S and Surolia, Avadhesha and Kremer, Laurent (2008) Antimycobacterial Activity and Mechanism of Action of $NAS-91^\nabla$. In: Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1162-1166.
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The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for \Delta9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.
|Item Type:||Journal Article|
|Additional Information:||copyright of this article belongs to American Society for Microbiology.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||26 Aug 2008|
|Last Modified:||19 Sep 2010 04:49|
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