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Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Kamal, A and Ahmed, SK and Reddy, KS and Khan, MNA and Shetty, RVCRNC and Siddhardha, B and Murty, USN and China, A and Nagaraja, V (2007) Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents. In: Letters in Drug Design & Discovery, 4 (8). pp. 550-556.

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Official URL: http://www.bentham.org/lddd/contabs/lddd4-8.htm#4

Abstract

A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Bentham Science Publishers.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 08 Oct 2008 10:00
Last Modified: 08 Oct 2008 10:00
URI: http://eprints.iisc.ernet.in/id/eprint/16081

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