Metal-Based Netropsin Mimics Showing AT-Selective DNA Binding and DNA Cleavage Activity at Red Light

Patra, Ashis K and Bhowmick, Tuhin and Ramakumar, Suryanarayanarao and Chakravarty, Akhil R (2007) Metal-Based Netropsin Mimics Showing AT-Selective DNA Binding and DNA Cleavage Activity at Red Light. In: Inorganic Chemistry:Communication, 46 (22). pp. 9030-9032.

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Abstract

Copper(II) bis-arginate $[Cu(L-arg)_2]$ $(NO_3)_2$(1) and [Cu(L-arg)(phen)-Cl]Cl (2) as mimics of the minor-groove-binding natural antibiotic netropsin show preferential binding to the AT-rich region of doublestranded DNA. The complexes with a d-d band near 600 nm display oxidative DNA cleavage activity on photoirradiation at UV-A light of 365 nm and at red light of 647.1 nm (Ar-Kr laser) in a metal-assisted photoexcitation process forming singlet oxygen $(^{1}O_2)$ species in a type-2 pathway.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to American Chemical Society.
Department/Centre:	Division of Information Sciences > BioInformatics Centre Division of Chemical Sciences > Inorganic & Physical Chemistry Division of Physical & Mathematical Sciences > Physics
Date Deposited:	18 Dec 2008 04:02
Last Modified:	19 Sep 2010 04:52
URI:	http://eprints.iisc.ernet.in/id/eprint/16514

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