Chandrasekhar, Sosale and Gopalaiah, Kovuru (2003) Beckmann reaction of oximes catalysed by chloral: mild and neutral procedures. In: Tetrahedron Letters, 44 (4). pp. 755-756.
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A variety of ketoximes undergo the Beckmann rearrangement when heated with 0.5 molar equiv. of chloral (neat melt/1\sim30°C), to furnish the corresponding amides in excellent yields (generally 80–95%) after simple work-up. (Aromatic aldoximes dehydrated to the corresponding nitriles in excellent yields under similar conditions.) The absence of solvent, Brønsted acids, strong Lewis acids and by-products, and a simple work-up characterise the procedures.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Keywords:||Beckmann rearrangement;catalytic;chloral;environmentally mild|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||05 Dec 2008 06:07|
|Last Modified:||19 Sep 2010 04:52|
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