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Bile Acid-Derived Molecular Tweezers: Study of Solvent Effects in Binding, and Determination of Thermodynamic Parameters by an Extraction-Based Protocol

Potluri, VijayKumar and Maitra, Uday (2000) Bile Acid-Derived Molecular Tweezers: Study of Solvent Effects in Binding, and Determination of Thermodynamic Parameters by an Extraction-Based Protocol. In: JOURNAL OF ORGANIC CHEMISTRY, 65 (23). pp. 7764-7769.

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Abstract

A family of bile acid-based molecular tweezers (1-3) were synthesized, and their binding affinities with picric acid in different solvents were evaluated using a simple extraction-based protocol. The binding affinities increased in nonpolar solvents. The size of the solvent molecule did not affect the binding constant. Thermodynamic parameters for the binding of picric acid in CCl$_{4} $ were also determined by this method. Binding constants of these tweezers with trinitrofluorenone in CDCl$_{3} $ were determined by NMR titration.

Item Type: Journal Article
Additional Information: Copy right belongs to American Chemical Society
Keywords: SYNTHETIC RECEPTORS;RECOGNITION;STABILITY;DESIGN;CONSTANTS;SIZE
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 08 Dec 2008 07:06
Last Modified: 29 Sep 2010 09:13
URI: http://eprints.iisc.ernet.in/id/eprint/16613

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