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Comparative genomics of Mycobacterium tuberculosis and Escherichia coli for recombination (rec) genes

Muniyappa, K and Vaze, MB and Ganesh, N and Sreedhar Reddy, M and Guhan, N and Venkatesh, R (2000) Comparative genomics of Mycobacterium tuberculosis and Escherichia coli for recombination (rec) genes. In: Microbiology Comment, 146 (9). pp. 2093-2095.

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Official URL: http://mic.sgmjournals.org/cgi/reprint/146/9/2093

Abstract

Despite the importance of \mathit{Mycobacterium tuberculosis} as a pathogen, the genetic basis of pathogenesis remains poorly understood. It is believed that allele exchange would facilitate understanding of the role(s) of specific genes that encode virulence determinants and help the conception of new therapeutic and prophylactic interventions. Although allele exchange has been achieved in \mathit{Mycobacterium smegmatis,} it has proved to be ineficient in \mathit{M. tuberculosis} due to the existence of an eæcient illegitimate recombination (IR) system. The molecular mechanism for the intrinsic resistance of\mathit{M. uberculosis} to allele exchange and increased frequency of IR remain obscure.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Society for General Microbiology.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 23 Dec 2008 06:08
Last Modified: 19 Sep 2010 04:53
URI: http://eprints.iisc.ernet.in/id/eprint/16678

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