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Analysis of weak interactions involving organic fluorine: Insights from packing features in substituted 4-keto-tetrahydroindoles

Chopra, Deepak and Nagarajan, K and Row, Guru TN (2008) Analysis of weak interactions involving organic fluorine: Insights from packing features in substituted 4-keto-tetrahydroindoles. In: Journal of Molecular Structure, 888 (1-3). pp. 70-83.

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Abstract

The role of ``organic fluorine'' in controlling the packing motifs in crystal structures which possess both strong and weak intra- and intermolecular interactions reveal that C-H center dot center dot center dot F hydrogen bonded networks provide additional stability. In this context, the crystal structures of seven new compounds have been investigated based on the molecular motif 1,5,6,7-tetrahydro-4H-indol-4-one with 4-fluorophenyl substitutions at the ``para'' position on the I-phenyl ring in four compounds and different substituents on the five-membered ring in the remaining three compounds. The features of conformational changes and the flexibility in packing based on C-H... 0, C-H center dot center dot center dot pi and C-H center dot center dot center dot F have been analyzed.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Weak interactions;Hydrogen bonds;Organic fluorine;Molecular conformation.
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 04 Dec 2008 04:49
Last Modified: 19 Sep 2010 04:53
URI: http://eprints.iisc.ernet.in/id/eprint/16764

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