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Facile Entry to 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones from Amines and Amino Acids

Sudhir, V Sai and Baig, Nasir RB and Chandrasekaran, Srinivasan (2008) Facile Entry to 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones from Amines and Amino Acids. In: European Journal of Organic Chemistry (14). pp. 2423-2429.

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Official URL: http://www3.interscience.wiley.com/journal/1179475...

Abstract

A practical and high-yielding regioselective synthesis ofseveral enantiopure 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones is described starting from primary amines and -amino acid derivatives in a three-step reaction sequence by employing a constrained intramolecular click reaction as the key step. The method obviates chromatographic purification of products.

Item Type: Journal Article
Additional Information: Copyright belongs to John Wiley and Sons.
Keywords: triazoles; alkynes; cycloaddition; nitrogen heterocycles; amino acids.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 19 Jul 2009 08:24
Last Modified: 19 Sep 2010 04:54
URI: http://eprints.iisc.ernet.in/id/eprint/16889

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