Facile Entry to 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones from Amines and Amino Acids

Sudhir, V Sai and Baig, Nasir RB and Chandrasekaran, Srinivasan (2008) Facile Entry to 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones from Amines and Amino Acids. In: European Journal of Organic Chemistry (14). pp. 2423-2429.

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Abstract

A practical and high-yielding regioselective synthesis ofseveral enantiopure 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones is described starting from primary amines and -amino acid derivatives in a three-step reaction sequence by employing a constrained intramolecular click reaction as the key step. The method obviates chromatographic purification of products.

Item Type:	Journal Article
Additional Information:	Copyright belongs to John Wiley and Sons.
Keywords:	triazoles; alkynes; cycloaddition; nitrogen heterocycles; amino acids.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	19 Jul 2009 08:24
Last Modified:	19 Sep 2010 04:54
URI:	http://eprints.iisc.ernet.in/id/eprint/16889

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