Saifi, Mustafa G and Veitia, Reiner and El khil, Houssein Khodjet and Barbaux, Sandrine and Tilak, Preetha and Thomas, Manorama I and Fellous, Marc (2000) sY116, a human Y-linked polymorphic STS. In: Journal of Genetics, 79 (1). pp. 17-20.
During a study of deletions of Y-chromosomal DNA in infertile males, sY116, a Y-linked STS, showed different electrophoretic mobilities in three males, two infertile and one fertile. A study of this STS among 35 other normal males showed that this locus is polymorphic. sY116 has a polya-rich stretch whose instability appears to be the most likely cause of this polymorphism. The possible usefulness of sY116 polymorphism in the detection of subtle genome-wide instabilities in some types of cancer is discussed.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Indian Academy of Sciences.|
|Keywords:||male infertility;polymorphism;Y chromosome;mitotic instability.|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||30 Sep 2004|
|Last Modified:||19 Sep 2010 04:15|
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