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First synthesis of phosphonobile acids and preliminary studies on their aggregation properties

Maitra, Uday and Babu, Ponnusamy (2003) First synthesis of phosphonobile acids and preliminary studies on their aggregation properties. In: Steroids, 68 (5). pp. 459-463.

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Abstract

The synthesis of three novel phosphonobile acids fromnatural bile acids is reported. The CMC of phosphonodeoxycholic acid (PDCA) at pH 8.2 was found to be lower than that of the parent deoxycholic acid (DCA). PDCA micelles were also found to have higher microviscosity compared to DCA micelles, suggesting higher hydrophobicity and tighter packing in the interior of PDCA micelles. PDCA aggregated further to form an aqueous gel at pH 4.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Aggregation;Arbuzov reaction;Bile acids;Aqueous gel; Phosphonic acids.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 21 Jul 2009 11:39
Last Modified: 19 Sep 2010 04:54
URI: http://eprints.iisc.ernet.in/id/eprint/16935

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