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Relaxation of arterial smooth muscle: A new function of a water-soluble degradation product of coenzyme Q (ubiquinone)

Bindu, R and Venkataraman, BV and Rao, Aparna VS and Ramasarma, T (2003) Relaxation of arterial smooth muscle: A new function of a water-soluble degradation product of coenzyme Q (ubiquinone). In: BioFactors, 18 (1-4). pp. 137-143.

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Abstract

Treatment of coenzyme Q with ozone yielded a degradation product having unmodified ring that retained its spectral characteristics and a truncated side-chain that made it water-soluble. This derivative, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. This effect offers an explanation for the known hypotensive action of exogenous coenzyme Q regardless of its side-chain length.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to IOS Press.
Keywords: coenzyme Q;ubiquinone;relaxation of arterial rings;water-soluble degradation product;BP lowering effect.
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Division of Biological Sciences > Biochemistry
Date Deposited: 31 Oct 2009 08:46
Last Modified: 31 Oct 2009 08:46
URI: http://eprints.iisc.ernet.in/id/eprint/17303

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