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Solvent effects on the lipase catalyzed biodegradation of poly (epsilon-caprolactone) in solution

Sivalingam, G and Chattopadhyay, Sujay and Madras, Giridhar (2003) Solvent effects on the lipase catalyzed biodegradation of poly (epsilon-caprolactone) in solution. In: Polymer Degradation and Stability, 79 (3). pp. 413-418.

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Abstract

The effect of various solvents on the biodegradation of poly (F-caprolactone) (PCL) was investigated at 45 degreesC using two different lipases: Novozyme 435 and Lipolase. The rate coefficients of polymer degradation and enzyme bdeactivation in acetone, toluene, benzene, benzyl alcohol, and acetone-water mixture were determined. Continuous distribution kinetics was proposed to model the deactivation of enzyme and polymer degradation and determine the rate coefficients. The effect of polarity and viscosity of the solvents on the degradation of the polymer was investigated. While the degradation rate decreased with viscosity, it increased with polarity for the solvents. The loss of enzymatic activity was less in Novozyme 435compared to lipolase in non-aqueous solvents. Both the enzymes were sensitive to the amount of water present in the system and showed the maximum degradation of the polymers at an optimum value concentration of 8.7 wt.% of water in acetone

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science
Keywords: enzymatic degradation;poly (epsilon-caprolactone);specific chain end scission;solvent effects;Novozyme-435;Lipolase.
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Date Deposited: 25 Nov 2009 07:36
Last Modified: 19 Sep 2010 04:56
URI: http://eprints.iisc.ernet.in/id/eprint/17359

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