Surolia, N and Surolia, A (2001) Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum. In: Nature Medicine, 7 (2). pp. 167-173.
Triclosan_offers.pdf - Published Version
Restricted to Registered users only
Download (1820Kb) | Request a copy
The antimicrobial biocide triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] potently inhibits the growth of Plasmodium falciparum in vitro and, in a mouse model, Plasmodium berghei in vivo. Inhibition of [C-14]acetate and [C-14]malonyl-CoA incorporation into fatty acids in vivo and in vitro, respectively, by triclosan implicate FabI as its target. Here we demonstrate that the enoyl-ACP reductase purified from P. falciparum is triclosan sensitive. Also, we present the evidence for the existence of FabI gene in P, falciparum. We establish the existence of the de novo fatty acid biosynthetic pathway in this parasite, and identify a key enzyme of this pathway for the development of new antimalarials.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Nature Medicine.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||11 Feb 2010 06:14|
|Last Modified:||19 Sep 2010 04:58|
Actions (login required)