Shenoy, Avinash R (2000) His kinase or mine? Histidine kinases through evolution. In: Journal of Biosciences, 25 (04). pp. 317-322.
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Sensing environmental changes and responding to them is the key to any organism’s survival. The simplest example of a sensor-response system is seen in bacteria in the form of what is known as the two-component system. This system involves proteins in which the sensor or component I detects the stimulus via its input or sensor domain and is trans-autophosphorylated on a conserved histidine. The sensor then transfers this phosphate to the response regulator, or component II, on a conserved aspartic acid residue (Hoch 2000).This His-Asp signal transduction pathway, though ubiquitous in prokaryotes, is rarely encountered in higher eukaryotes.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Indian Academy of Sciences.|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)|
|Date Deposited:||01 Sep 2009 06:44|
|Last Modified:||19 Sep 2010 04:58|
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