Venkateswarlu, D and Lyngdoh, RHD and Bansal, M (1997) A semi-empirical SCF-MO study on the base-pairing properties of 8-oxopurines: Significance for mutagenicity. In: Journal Of The Chemical Society-Perkin Transactions 2 (3). pp. 621-626.
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C-8-Oxidised purines like 7-hydro-8-oxoguanine (8OG)and 7-hydro-8-oxoadenine (8OA) are known as products of oxidative DNA damage. Semiempirical molecular orbital calculations at the PM3 SCF-MO level are used to investigate the base-pairing properties of these bases in an attempt to understand their mutagenic properties. A detailed analysis of the base-pairing properties of these bases leads to an identification of the most probable pairing schemes involved in mutagenic base-mispairing. It is suggested that both bases are capable of inducing transversional as well as transitional mutations via base-mispairing. The results presented are largely in consonance with available experimental reports.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Royal Society of Chemistry.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||10 Feb 2010 07:04|
|Last Modified:||19 Sep 2010 05:01|
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