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ppGpp: Stringent response and survival

Jain, Vikas and Kumar, Manish and Chatterji, Dipankar (2006) ppGpp: Stringent response and survival. In: Journal Of Microbiology, 44 (1). pp. 1-10.

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Abstract

Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms, with such changes generating a quick and suitable response, which guides the physiology of bacteria. During nutritional deprivation, bacteria show a stringent response, as characterized by the accumulation of (p)ppGpp, resulting in the repression of stable RNA species, such as rRNA and tRNA, with a concomitant change in colony morphology. However, genes involved in amino acid biosynthesis become over-expressed to help bacteria survive under such conditions. The survivability of pathogenic bacteria inside a host cell also depends upon the stringent response demonstrated. Therefore, an understanding of the physiology of stringent conditions becomes very interesting in regulation of the growth and persistence of such invading pathogens.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Microbiology Society Of Korea.
Keywords: Rel protein;stringent response;(p)ppGpp;omega subunit.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 06 Apr 2009 10:18
Last Modified: 19 Sep 2010 05:02
URI: http://eprints.iisc.ernet.in/id/eprint/18470

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