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Cadmium-induced lipid peroxidation and the antioxidant enzymes in rat tissues: Role of vitamin E and selenium

Sarkar, S and Poonam, Y and Bhatnagar, D (1997) Cadmium-induced lipid peroxidation and the antioxidant enzymes in rat tissues: Role of vitamin E and selenium. In: Trace Elements And Electrolytes, 14 (1). pp. 41-45.

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Official URL: http://www.dustri.com/nc/journals-in-english/mag/t...

Abstract

Cadmium (Cd) induced lipid peroxidation (LPO) and oxidative damage in various tissues by altering the antioxidant status of the cells. Rats were pretreated with vitamin E and/or Se, prior to Cd treatment to prepare the animals to withstand the oxidative assault. A Cd intoxication increased LPO in liver, kidney, and heart and diminished the activities of superoxide dismutase (SOD), catalase (CAT), total and Se-dependent glutathione peroxidase (GSH-Px) in these tissues. The Cd-induced LPO decreased and the antioxidant enzyme activity increased when animals were treated with vitamin F and/or Se prior to Cd intoxication. The animals treated with vitamin E and/or Se without Cd intoxication showed LPO and antioxidant enzyme activities comparable to control animals. The results show that Cd induces LPO and alters the antioxidant system in tissues, however, the presence of adequate vitamin E and/or Se ameliorates the oxidative effects of Cd.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Dustri Verlag.
Keywords: Catalase;glutathione peroxidase;lipid peroxidation;superoxide dismutase
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Division of Biological Sciences > Biochemistry
Date Deposited: 29 May 2009 05:22
Last Modified: 01 Mar 2010 12:30
URI: http://eprints.iisc.ernet.in/id/eprint/18571

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