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Hepatoprotective effect of C-phycocyanin: Protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicity in rats

Vadiraja, Bhat B and Gaikwad, Nilesh W and Madyastha, KM (1998) Hepatoprotective effect of C-phycocyanin: Protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicity in rats. In: Biochemical and Biophysical Research Communications, 249 (02). pp. 428-431.

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Abstract

Effect of C-phycocyanin (from Spirulina platensis) pretreatment on carbontetrachloride and R-(+)-pulegone-induced hepatotoxicity in rats was studied, Intraperitoneal (i.p.) administration (200 mg/kg) of a single dose of phycocyanin to rats, one or three hours prior to R-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals. For instance, serum glutamate pyruvate transaminase (SGPT) activity was almost equal to control values. The losses of microsomal cytochrome P450, glucose-6-phosphatase and aminopyrine-N-demethylase were significantly reduced, suggesting that phycocyanin provides protection to liver enzymes, It was noticed that the level of menthofuran, the proximate toxin of R-(+)-pulegone was nearly 70% more in the urine samples collected from rats treated with R-(+)-pulegone alone than rats treated with the combination of phycocyanin and R-(+)-pulegone. The possible mechanism involved in the hepatoprotection is discussed.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Spirulina platensis;C-phycocyanin;carbon tetrachloride;R-(+)-pulegone, a monoterpene ketone; hepatotoxicity;hepatoprotective effect.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 11 Aug 2009 11:21
Last Modified: 19 Sep 2010 05:24
URI: http://eprints.iisc.ernet.in/id/eprint/18691

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