Lal, G and Shaila, MS and Nayak, R (2006) Activated mouse T cells downregulate, process and present their surface TCR to cognate anti-idiotypic CD4(+) T cells. In: Immunology And Cell Biology, 84 (2). pp. 145-153.Full text not available from this repository.
The ability of activated T cells to present foreign antigens through the MHC class II pathway has been shown in the case of human, rat and mouse T cells. In the present study, the ability of activated T cells to present their endogenous TCR in association with MHC class II molecules to CD4(+) T cells was shown. Upon activation mouse T cells downregulate their surface TCR, which are degraded into peptides in endosomal/lysosomal compartments. The idiopeptides (peptides derived from the variable region of the TCR) are presented to cognate anti-idiotypic CD4(+) T cells, resulting in activation and proliferation of these cells. Interaction of idiotypic and anti-idiotypic T cells brought about by presentation of TCR idiopeptide may have important implications for T-cell vaccination and perpetuation of T-cell memory not requiring persisting antigen or long-lived memory cells.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Blackwell Publishong|
|Keywords:||Cell Biology;Immunology;antigen presentation;anti-idiotypic T cell;T-cell memory;T-cell receptor(TCR)|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||13 Feb 2009 07:38|
|Last Modified:||13 Feb 2009 07:38|
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