Bhandari, Rashna and Mathew, Roy and Vijayachandra, K and Visweswariah, Sandhya S (2000) Tyrosine phosphorylation of the human guanylyl cyclase C receptor. In: Journal Of Biosciences, 25 (4). pp. 339-346.
Tyrosine phosphorylation events are key components of several cellular signal transduction pathways. This study describes a novel method for identification of substrates for tyrosine kinases. Go-expression of the tyrosine kinase EphB1 with the intracellular domain of guanylyl cyclase C (GCG) in Escherichia coli cells resulted in tyrosine phosphorylation of GCC, indicating that GCC is a potential substrate for tyrosine kinases. Indeed, GGC expressed in mammalian cells is tyrosine phosphorylated, suggesting that tyrosine phosphorylation may play a role in regulation of GCC signalling. This is the first demonstration of tyrosine phosphorylation of any member of the family of membrane-associated guanylyl cyclases.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Indian Academy of Sciences.|
|Keywords:||EphB1;guanylyl cyclase C;tyrosine phosphorylation|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)|
|Date Deposited:||03 Sep 2004|
|Last Modified:||19 Sep 2010 04:16|
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