Tyrosine phosphorylation of the human guanylyl cyclase C receptor

Bhandari, Rashna and Mathew, Roy and Vijayachandra, K and Visweswariah, Sandhya S (2000) Tyrosine phosphorylation of the human guanylyl cyclase C receptor. In: Journal Of Biosciences, 25 (4). pp. 339-346.

Preview

PDF Tyrosine.pdf Download (2311Kb)

Abstract

Tyrosine phosphorylation events are key components of several cellular signal transduction pathways. This study describes a novel method for identification of substrates for tyrosine kinases. Go-expression of the tyrosine kinase EphB1 with the intracellular domain of guanylyl cyclase C (GCG) in Escherichia coli cells resulted in tyrosine phosphorylation of GCC, indicating that GCC is a potential substrate for tyrosine kinases. Indeed, GGC expressed in mammalian cells is tyrosine phosphorylated, suggesting that tyrosine phosphorylation may play a role in regulation of GCC signalling. This is the first demonstration of tyrosine phosphorylation of any member of the family of membrane-associated guanylyl cyclases.

Item Type:	Journal Article
Additional Information:	Copyright for this article belongs to Indian Academy of Sciences.
Keywords:	EphB1;guanylyl cyclase C;tyrosine phosphorylation
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Date Deposited:	03 Sep 2004
Last Modified:	19 Sep 2010 04:16
URI:	http://eprints.iisc.ernet.in/id/eprint/1905

Actions (login required)

View Item