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Drug-lipid interactions in the model membrane, DPPC-water: A DSC and proton NMR study

Deniz, KU and Panicker, L and Parvathanathan, PS and Datta, G and Vivekanandan, S and Ramanathan, KV and Khetrapal, CL (1996) Drug-lipid interactions in the model membrane, DPPC-water: A DSC and proton NMR study. In: Molecular Crystals And Liquid Crystals Science And Technology Section A-Molecular Crystals And Liquid Crystals, 288 . pp. 237-247.

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Abstract

The interactions of the keratolytic drug Salicylic Acid (SA) and the antifungal drugs Methyl Paraben (MPB) and Propyl Paraben (PPB) with the model membrane, DPPC-Water, have been studied using DSC and H-1 NMR. The results show that these drug molecules are situated near the membrane interface with their polar group(s) interacting with the vicinal water, while the aromatic regions and the methyl and propyl groups of MPB and PPB interact with the neighbouring hydrophobic regions of the DPPC molecule. The strength of interaction of the aromatic group is in the order PPB > MPB > SA.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Taylor and Francis Group.
Department/Centre: Division of Chemical Sciences > Sophisticated Instruments Facility
Date Deposited: 01 Jun 2009 08:36
Last Modified: 01 Jun 2009 08:36
URI: http://eprints.iisc.ernet.in/id/eprint/19110

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