Shanker, Y Gopi and Shetty, Usha P and Rao, A Jagannadha (1998) Regulation of low density lipoprotein receptor mRNA levels by estradiol 17 beta and chorionic gonadotropin in human placenta. In: Molecular and Cellular Biochemistry, 187 (1-2). pp. 133-139.
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Inhibition of synthesis of estradiol 17 beta by the addition of inhibitors of aromatase, a key enzyme in the biosynthesis of estradiol 17 beta, or addition of tamoxifen - an estrogen receptor antagonist, to human placental minces resulted in an increase in the level of LDL-receptor mRNA. This increase could be blocked by the simultaneous addition of estradiol 17 beta. A concentration dependent effect of estradiol 17 beta on the level of LDL-receptor mRNA was seen both in first trimester, and term placenta. Addition of human chorionic gonadotropin (hCG) to term placental minces also increased the LDL-receptor mRNA levels. When hCG and cycloheximide were added together, an additive effect was observed. The results obtained in this study suggest that the LDL-receptor mRNA levels in the human placenta are regulated by estradiol 17 beta and hCG.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Springer.|
|Keywords:||LDL-receptor;estradiol 17 beta;human chorionic gonadotropin; human placenta;progesterone synthesis.|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Division of Biological Sciences > Biochemistry
|Date Deposited:||31 Dec 2009 07:33|
|Last Modified:||19 Sep 2010 05:26|
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