Haveli, SD and Roy, S and Chandrasekaran, Srinivasan (2009) Synthesis of Unnatural C-2 Amino Acid Nucleosides Using NIS-Mediated Ring Opening of 1,2-Cyclopropane Carboxylated Sugar Derivatives. In: Synlett (3). pp. 451-455.
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We have developed a general and efficient method for the stereoselective construction of pyrimidine-based pyranosyl C-2 amino acid nucleosides using NIS-mediated ring opening of 1,2-cyclopropanated sugar derivatives. This methodology has been successfully extended to the synthesis of furanosyl nucleosides, Which have potential applications in the development of novel, nontoxic antifungal therapeutics.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Georg Thieme Verlag.|
|Keywords:||Uracil Polyoxin C; Organic-Synthesis; Nikkomycin-B; Saccharomyces-Cerevisiae; Antifungal Activity; Antibiotics; Cyclopropanes|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||03 Jan 2010 09:44|
|Last Modified:||19 Sep 2010 05:29|
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