Haveli, SD and Roy, S and Chandrasekaran, Srinivasan (2009) Synthesis of Unnatural C-2 Amino Acid Nucleosides Using NIS-Mediated Ring Opening of 1,2-Cyclopropane Carboxylated Sugar Derivatives. In: Synlett (3). pp. 451-455.
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Abstract
We have developed a general and efficient method for the stereoselective construction of pyrimidine-based pyranosyl C-2 amino acid nucleosides using NIS-mediated ring opening of 1,2-cyclopropanated sugar derivatives. This methodology has been successfully extended to the synthesis of furanosyl nucleosides, Which have potential applications in the development of novel, nontoxic antifungal therapeutics.
| Item Type: | Journal Article |
|---|---|
| Additional Information: | Copyright for this article belongs to Georg Thieme Verlag. |
| Keywords: | Uracil Polyoxin C; Organic-Synthesis; Nikkomycin-B; Saccharomyces-Cerevisiae; Antifungal Activity; Antibiotics; Cyclopropanes |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 03 Jan 2010 09:44 |
| Last Modified: | 19 Sep 2010 05:29 |
| URI: | http://eprints.iisc.ernet.in/id/eprint/19714 |
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