Krishnamurthy, Kavita and Surolia, Namita and Adiga, Radhakantha P (1984) Mechanism of foetal wastage following immunoneutralization of riboflavin carrier protein in the pregnant rat: disturbances in flavin coenzyme levels. In: FEBS Letters, 178 (1). pp. 87-91.
3fulltext.pdf - Published Version
Restricted to Registered users only
Download (462Kb) | Request a copy
Immunoneutralization of maternal RCP results in a >90% decrease in the content and the incorporation of [2-14C]riboflavin into embryonic FAD as well as a percentage redistribution of both embryonic FMN and riboflavin. This is unaccompanied by any discernible changes in flavin distribution pattern in the maternal liver. Embryonic α-glycerophosphate dehydrogenase and NADPH-cytochrome c reductase register significant decreases in activities in the RCP antiserum-treated rats. These alterations readily explain the arrest of foetal growth culminating in pregnancy termination in the antiserum-treated animals.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs Elsevier science.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||03 Feb 2010 09:42|
|Last Modified:||01 Mar 2012 07:46|
Actions (login required)