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Crystalline A-DNA: The X-Ray Analysis of the Fragment d(G-G-T-A-T-A-C-C)

Zippora, Shakkedt and Cruses, WBT and Rabinovicht, D and Olga, Kennards and Egertt, E and Salisburyt, SA and Graciela, Salai and Viswamitrata, MA (1981) Crystalline A-DNA: The X-Ray Analysis of the Fragment d(G-G-T-A-T-A-C-C). In: Proceedings of the Royal Society of London. Series B, Biological Sciences,, 213 (1193). pp. 479-487.

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Abstract

An A-DNA type double helical conformation was observed in the single crystal X-ray structure of the octamer d(G-G-T-A-T-A-C-C), 1, and its 5-bromouracil-containing analogue, 2. The structure of the isomorphous crystals (space group P61) was solved by a search technique based on packing criteria and R-factor calculations, with use of only low order data. At the present stage of refinement the R factors are 31 % for 1 and 28 % for 2 at a resolution of 2.25 A (0.225 nm). The molecules interact through their minor grooves by hydrogen bonding and base to sugar van der Waals contacts. The stable A conformation observed in the crystal may have some structural relevance to promoter regions where the T-A-T-A sequence is frequently found.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to The Royal Society London
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 30 May 2009 06:36
Last Modified: 09 Jan 2013 05:30
URI: http://eprints.iisc.ernet.in/id/eprint/20131

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