Ramesh, N and Bramachari, SK (1983) Critical Cation Balance In B-]Z Transition - Role Of Li+. In: FEBS Letters, 164 (1). 33-37.
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The sodium salt of poly(dG-dC) is known to exhibit a B + Z transition in the presence of various cations and 60% alcohol. We here show that the lithium salt of poly(dG-dC) does not undergo B 4 Z transition in the presence of 60% alcohol since Li’ with its large hydration shell cannot stabilize the Z-form. On the other hand, high concentrations of Mg2* or micromolar concentrations of the cobalt hexamine complex which are known to stabilize the Z-form can compete with Li+ for charge neutraIization and hence bring about a B--t Z transition in the same polymer. From the model building studies the mode of action of the cobalt-hexamine complex in stabilizing the Z-form is postulated.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to EIsevier Science.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||30 May 2009 05:56|
|Last Modified:||19 Sep 2010 05:32|
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