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Optically active gossypol as a circular dichroism probe of interactions with serum albumins

Whaley, Kevin J and Sampatha, DS and Balaram, P (1984) Optically active gossypol as a circular dichroism probe of interactions with serum albumins. In: Biochimica et Biophysica Acta, 801 (1). pp. 127-130.

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Abstract

The (+)-enantiomer of the polyphenolic binaphthyl gossypol, has been shown to be a useful CD probe of interactions with human and bovine serum albumin. (+)-Gossypol binds to albumin with same affinity as recemic (±)-gossypol, as shown by fluorescence quenching, and also displaces bilirubin from its albumin binding site. The CD characteristics of bound gossypol are different in the case of the two proteins.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 03 Feb 2010 12:15
Last Modified: 19 Sep 2010 05:34
URI: http://eprints.iisc.ernet.in/id/eprint/20709

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