Marathe, Arvind and Karandur, Deepti and Bansal, Manju (2009) Small local variations in B-form DNA lead to a large variety of global geometries which can accommodate most DNA-binding protein motifs. In: BMC Structural Biology, 9 (24).
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An important question of biological relevance is the polymorphism of the double-helical DNA structure in its free form, and the changes that it undergoes upon protein-binding. We have analysed a database of free DNA crystal structures to assess the inherent variability of the free DNA structure and have compared it with a database of protein-bound DNA crystal structures to ascertain the protein-induced variations.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to BioMed Central.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||07 Jan 2010 09:59|
|Last Modified:||19 Sep 2010 05:36|
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