Francis, AK and Rao, Ch Pulla and Iqbal, M and Nagaraj, R and Vijayan, M and Balaram, P (1982) Helical conformations of three crystalline pentapeptide fragments of suzukacillin, a membrane channel forming polypeptide. In: Biochemical and Biophysical Research Communications, 106 (4). pp. 1240-1247.
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The crystal structures of three pentapeptide fragments of suzukacillin-A have been determined. Boc-Aib-Pro-Val-Aib-Val-OMe (peptide 1–5) adopts a distorted helical conformation, stabilized by three intramolecular hydrogen bonds (two 5→1, one 4→1). Boc-Ala-Aib-Ala-Aib-Aib-OMe (peptide 6–10) and Boc-Leu-Aib-Pro-Val-Aib-OMe (peptide 16–20) adopt 310 helical structures stabilized by three and two 4→1 intramolecular hydrogen bonds, respectively. These structures provide substantial support for a largely helical conformation for the suzukacillin membrane channel.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Chemical Sciences > Solid State & Structural Chemistry Unit|
|Date Deposited:||11 Aug 2009 10:56|
|Last Modified:||19 Sep 2010 05:37|
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