Mittal, Balraj and Kurup, CK Ramakrishna (1980) Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria. In: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 619 (1). pp. 90-97.
fulltext.pdf - Published Version
Restricted to Registered users only
Download (559Kb) | Request a copy
The enzyme carnitine acetyltransferase (acetyl-CoA:carnitine O-acetyltransferase, EC 188.8.131.52) has been purified to homogeneity from hepatic mitochondria of clofibrate-fed rats. It is a protein of molecular weight 56 000 composed of two non-identical subunits of molecular weight 34 000 and 25 000. The enzyme is inhibited by palmityl-CoA as well as acetyl carnitine. The inhibition by fatty acyl-CoA is competitive with respect to both the substrates, carnitine and acetyl-CoA. The inhibition by acetylcarnitine is reversed by carnitine but not by acetyl-CoA.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||Clofibrate induction; Carnitine acetyltransferase; (Rat liver mitochondria)|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||28 Jan 2010 09:46|
|Last Modified:||19 Sep 2010 05:38|
Actions (login required)