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Theoretical studies on the conformation of beta-D-N-acetyl neuraminic acid (sialic acid)

Veluraja, K and Rao, VSR (1980) Theoretical studies on the conformation of beta-D-N-acetyl neuraminic acid (sialic acid). In: Biochimica et Biophysica Acta (BBA) - General Subjects, 630 (3). pp. 442-446.

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Abstract

The possible conformations of sialic acid were analysed using semi-empirical potential functions. The solid state conformation has approx. 0.2 kcal/mol higher energy than the minimum energy conformation. These studies suggest that in solution sialic acid may exist preponderantly in two different conformations which differ in the orientation of the terminal hydroxymethyl group of glycerol side-chain. The present model is consistent with 1H- and 13C-NMR data, but differs from the earlier models.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Keywords: Acetyl neuraminic acid; Sialic acid; Carbohydrate conformation
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 30 Oct 2009 10:17
Last Modified: 19 Sep 2010 05:38
URI: http://eprints.iisc.ernet.in/id/eprint/21728

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