Muhammed, H and Ramasarma, T and Kurup, CK Ramakrishna (1982) A hexokinase effect in the inhibition of oxidative phosphorylation in heart muscle mitochondria by Adriamycin. In: Biochemical and Biophysical Research Communications, 105 (4). 1440 -1445.
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Abstract
The inhibitory action of the anticancer antibiotic, Adriamycin, on succinate-dependent oxidative phosphorylation in heart mitochondria was markedly potentiated by the presence of hexokinase in the reaction medium. This 'hexokinase effect' was not observed in the oxidation of NAD+-linked substrates, or when liver or kidney mitochondria were used in place of heart mitochondria. These results offer a biochemical explanation for the extreme cardiac toxicity of the drug.
| Item Type: | Journal Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Elsevier Science. |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 27 Jul 2009 16:35 |
| Last Modified: | 19 Sep 2010 05:38 |
| URI: | http://eprints.iisc.ernet.in/id/eprint/21759 |
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