Muhammed, H and Ramasarma, T and Kurup, CK Ramakrishna (1982) A hexokinase effect in the inhibition of oxidative phosphorylation in heart muscle mitochondria by Adriamycin. In: Biochemical and Biophysical Research Communications, 105 (4). 1440 -1445.
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The inhibitory action of the anticancer antibiotic, Adriamycin, on succinate-dependent oxidative phosphorylation in heart mitochondria was markedly potentiated by the presence of hexokinase in the reaction medium. This 'hexokinase effect' was not observed in the oxidation of NAD+-linked substrates, or when liver or kidney mitochondria were used in place of heart mitochondria. These results offer a biochemical explanation for the extreme cardiac toxicity of the drug.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||27 Jul 2009 16:35|
|Last Modified:||19 Sep 2010 05:38|
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