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N-[2-naphthyl]-glycine hydrazide, a potent inhibitor of dna-dependent rna-polymerase of mycobacterium-tuberculosis h37rv

Prabhu, R and Rao, GR and Jamaluddin, M and Ramakrishnan, T (1986) N-[2-naphthyl]-glycine hydrazide, a potent inhibitor of dna-dependent rna-polymerase of mycobacterium-tuberculosis h37rv. In: Journal of Biosciences, 10 (1). 163 -166.

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Official URL: http://medind.nic.in/imvw/imvw22555.html

Abstract

N-[2-Naphthyl]-glycine hydrazide has been shown for the first time as a potent inhibitor of the DNA-dependent RNA polymerase (EC 2.7.7.6) of Mycobacterium tuberculosis H37Rv. At a concentration of 10 to the power -9 M, the compound shows maximum inhibition of the enzyme, the inhibition being less at higher concentrations. It is suggested that the novel type of inhibition pattern may be due to hydrophobic interactions occurring between the molecules of the compound at higher concentrations. The finding that there is a shift in the max of the compound could also account for this phenomenon. The effect of this compound was also tested on DNA-dependent RNA polymerases from an eukaryotic fungus, Microsporum canis. At a concentration of 10 to the power-9 M it inhibits RNA polymerase II (32 percent) but not RNA polymerases I and III.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Mycobacterium tuberculosis;Microsporum; DNA-Directed RNA Polymerase;RNA Polymerase II;Laboratory chemicals;Data Interpretation, statistical;Animal.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 01 Feb 2010 07:43
Last Modified: 01 Feb 2010 07:43
URI: http://eprints.iisc.ernet.in/id/eprint/22198

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