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Antifertility effect of tamoxifen as tested in the female bonnet monkey (Macaca radiata)

Ravindranath, N and Moudgal, NR (1986) Antifertility effect of tamoxifen as tested in the female bonnet monkey (Macaca radiata). In: Journal of Biosciences, 10 (1). 167 -170.

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Abstract

The administration of a potent antiestrogen, tamoxifen at a dose of 3 mg/kg body weight/day orally post-coitally to cycling mated bonnet monkeys(Macaca radiata) from days 18–30 of cycle resulted in inhibition of establishment of pregnancy in 9 out of 10 monkeys. Tamoxifen effect was not due to interference with luteal function. The effect was specific to tamoxifen as exogenously administered progesterone could not reverse it. In addition to suggesting a role for estrogen in maintenance of early pregnancy in the primate the present study could be a prelude to the development of an effective post-ovulatory approach for regulation of fertility in the human female

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Antiestrogen;implantation;pregnancy;primate;post-coital contraception.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 26 Aug 2009 12:14
Last Modified: 19 Sep 2010 05:40
URI: http://eprints.iisc.ernet.in/id/eprint/22201

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