Structures of isopropylidene nucleoside derivatives - implications for ribose ring flexibility under external cyclic constraints

Viswamitra, MA and Gautham, N (1984) Structures of isopropylidene nucleoside derivatives - implications for ribose ring flexibility under external cyclic constraints. In: Proceedings of the Indian Academy of Sciences - Chemical Sciences, 93 (3). pp. 261-269.

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Abstract

Crystal structures of six isopropylidene nucleoside derivatives are described. The results show that, under external cyclic constraints, the ribose assumes a variety of unusual conformations. In those compounds which possess a base-to-sugar cyclization through the C(4′) atom, the furanose pucker is predominantly C(4′)-endo, O(4′)-exo. The possible relevance of the sulphur geometry in two of the compounds to certain structural aspects of the action of the enzyme thymidylate synthetase is also pointed out.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to Indian Academy Sciences.
Keywords:	Crystal structure;isopropylidene nucleoside derivatives;ribose ring flexibility;sulphur geometry;external cyclization.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	09 Feb 2010 11:11
Last Modified:	19 Sep 2010 05:41
URI:	http://eprints.iisc.ernet.in/id/eprint/22376

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