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Advances in gene delivery through molecular design of cationic lipids

Bhattacharya, Santanu and Bajaj, Avinash (2009) Advances in gene delivery through molecular design of cationic lipids. In: Chemical Communications (31). pp. 4632-4656.

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Abstract

This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure-activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 20 Aug 2009 10:45
Last Modified: 19 Sep 2010 05:42
URI: http://eprints.iisc.ernet.in/id/eprint/22463

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