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Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes

Chadha, A and Madhava Madyastha, K (1984) Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes. In: Xenobiotica, 14 (5). pp. 365-374.

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Abstract

1. Metabolites isolated from the urine of rats after oral administration of geraniol (I) were: geranic acid (II), 3-hydroxy-citronellic acid (III), 8-hydroxy-geraniol (IV), 8-carboxy-geraniol (V) and Hildebrandt acid (VI). 2. Metabolites isolated from urine of rats after oral administration of linalool (VII) were 8-hydroxy-linalool (VIII) and 8-carboxy-linalool (IX). 3. After three days of feeding rats with either geraniol or linalool, liver-microsomal cytochrome P-450 was increased. Both NADH- and NADPH-cytochrome c reductase activities were not significantly changed during the six days of treatment. 4. Oral administration of these two terpenoids did not affect any of the lung-microsomal parameters measured.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Taylor and Francis Group.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 22 Jan 2010 05:42
Last Modified: 22 Jan 2010 05:42
URI: http://eprints.iisc.ernet.in/id/eprint/22852

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