Podder, SK and Basu, HS (1984) Specificity of protein - Nucleic acid interaction and the biochemical evolution. In: Origins of Life and Evolution of Biospheres, 14 (1-4). pp. 477-484.
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The water soluble carbodiimide mediated condensation of dipeptides of the general form Gly-X was carried out in the presence of mono- and poly-nucleotides. The observed yield of the tetrapeptide was found to be higher for peptide-nucleotide system of higher interaction specificity following mainly the anticodon-amino acid relationship (Basu, H.S. & Podder, S.K., 1981, Ind. J. Biochem. Biophys.,19, 251-253). The yield of the condensation product of L-peptide was more because of its higher interaction specificity. The extent of the racemization during the condensation of Gly-L-Phe, Gly-L-Tyr and Gly-D-Phe was found to be dependent on the specificity of the interaction -the higher the specificity, the lesser the racemization. The product formed was shown to have a catalytic effect on the condensation reaction. These data thus provide a mechanism showing how the specific interaction between amino acids/dipeptides and nucleic acids could lead to the formation of the lsquoprimitiversquo translation machinery.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Springer.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||29 Jan 2010 06:12|
|Last Modified:||19 Sep 2010 05:43|
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