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Comparative genomics and functional roles of the ATP-dependent proteases Lon and Clp during cytosolic protein degradation

Chandu, Dilip and Nandi, Dipankar (2004) Comparative genomics and functional roles of the ATP-dependent proteases Lon and Clp during cytosolic protein degradation. In: Research in Microbiology, 155 . pp. 710-719.

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Abstract

The general pathway involving adenosine triphosphate (ATP)-dependent proteases and ATP-independent peptidases during cytosolic protein degradation is conserved, with differences in the enzymes utilized, in organisms from different kingdoms. Lon and caseinolytic protease (Clp) are key enzymes responsible for the ATP-dependent degradation of cytosolic proteins in Escherichia coli. Orthologs of E. coli Lon and Clp were searched for, followed by multiple sequence alignment of active site residues, in genomes from seventeen organisms, including representatives from eubacteria, archaea, and eukaryotes. Lon orthologs, unlike ClpP and ClpQ, are present in most organisms studied. The roles of these proteases as essential enzymes and in the virulence of some organisms are discussed.

Item Type: Journal Article
Additional Information: The copyright of this article belongs to Elsevier Science.
Keywords: ATP-dependent proteases;Clp;Comparative and functional genomics;Cytosolic protein degradation;Lon
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 11 Nov 2004
Last Modified: 19 Sep 2010 04:17
URI: http://eprints.iisc.ernet.in/id/eprint/2316

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